
段贤春,男,1981年7月出生,博士,副教授,副主任药师,硕士生导师,安徽省学术和技术带头人后备人选,主要从事中药药理学研究。主持国家自然科学基金面上项目、安徽省自然科学基金青年项目等各类科研课题10余项,以第一作者或通讯作者发表论文30余篇(SCI收录15篇);获安徽省自然科学二等奖1项、中华中医药学会科技进步三等奖1项,国家发明专利1项(第一专利权人);参编高等中医药院校规划教材3部、学术著作5部(其中1部为副主编)、网络药理学研究方法标准1部,取得省级科研成果7项。多年来主要围绕中药复方物质基础及作用机制开展相关探索,逐渐凝练出以下研究方向:(1)中药复方网络药理学与系统生物学研究;(2)中医药防治缺血性中风的作用及机制研究;(3)医院药学研究。
1、主要社会兼职情况
现任世界中医药学会联合会网络药理学专业委员会常务理事、副秘书长,中华中医药学会青年委员、中华中医药学会中药实验药理分会青年委员,安徽省药理学会理事,安徽省药学会医院药学专业委员会秘书长。同时担任《江苏大学学报》(医学版)、《中国药房》(网络版)编委,Journal of Ethnopharmacology、Frontiers in Pharmacology、Journal of Separation Science、BioMed Research International等学术期刊审稿专家,国家自然科学基金项目函审专家。
2、近年来主持科研项目情况
(1)国家自然科学基金面上项目/基于circDnajc1/miR-27a-5p/C1qc信号轴探讨小胶质细胞活化在缺血性中风神经元凋亡中的作用及桃红四物汤调控机制/2021年1月~2024年12月/55万/主持;
(2)安徽高校省级自然科学研究(重点)项目/基于网络药理学研究桃红四物汤防治缺血性中风主要物质基础及作用机制/2019年7月~2021年6月/6万/主持;
(3)安徽省教育厅/高校优秀拔尖人才培育项目/2019年7月~2021年6月/3万/主持;
(4)安徽省自然科学基金青年项目/基于PICK1蛋白与GluR2亚基研究三七超临界萃取物神经保护作用及机制/2015年1月~2016年12月/7万/主持;
(5)安徽高校省级自然科学研究(重点)项目/基于PICK1蛋白调控AMPA受体研究人参炔醇神经保护作用及其机制/2014年1月~2015年12月/5万/主持;
(6)安徽省省级中医发展专项经费项目/芪贞降糖颗粒质量控制及主要药效学研究/2014年1月~2015年12月/5万/主持;
(7)安徽省康缘中医药科技创新基金项目/治疗围绝经期综合征的紫参胶囊研制开发/2010年1月~2011年12月/10万/主持。
3、近年来发表有代表性学术论文
[1]Ni Wang, Furui Chu, Lijuan Zhang, Changyi Fei, Chao Yu, Sujun Xue, Yongzhong Wang, Ling Fang, Daiyin Peng, Xianchun Duan*, and Weidong Chen*. Taohong siwu decoction attenuates AIM2 and NLRC4 inflammasomes by ameliorates deoxyribonucleic acid damage after ischemic stroke. Frontiers in Pharmacology. 2022. 13: p. 954867.(通讯作者)
[2]Lingyu Pan, Can Peng, Lei Wang, Lili Li, Shi Huang, Changyi Fei, Ni Wang, Furui Chu, Daiyin Peng, Xianchun Duan*. Network pharmacology and experimental validation-based approach to understand the effect and mechanism of Taohong Siwu Decoction against ischemic stroke. Journal of Ethnopharmacology. 2022. 294: p. 115339.(通讯作者)
[3]Ni Wang, Furui Chu, Changyi Fei, Lingyu Pan, Yongzhong Wang, Weidong Chen, Daiyin Peng, Xianchun Duan*, Ling He*. Naoluo Xintong decoction in the treatment of ischemic stroke: A network analysis of the mechanism of action. Frontiers in Pharmacology. 2022. 13: p. 809505.(通讯作者)
[4]Shi Huang, Yan Chen, Lingyu Pan, Changyi Fei, Ni Wang, Furui Chu, Daiyin Peng, Xianchun Duan*, Yongzhong Wang*. Exploration of the Potential Mechanism of Tao Hong Si Wu Decoction for the Treatment of Breast Cancer Based on Network Pharmacology and In Vitro Experimental Verification. Frontiers in Oncology. 2021. 11: p. 731522.(通讯作者)
[5]Ni Wang, Changyi Fei, Furui Chu, Shi Huang, Lingyu Pan, Daiyin Peng, Xianchun Duan*. Taohong Siwu Decoction Regulates Cell Necrosis and Neuroinflammation in the Rat Middle Cerebral Artery Occlusion Model. Frontiers in Pharmacology. 2021. 12: p. 732358.(通讯作者)
[6]Xinkui Liu, Yang Wu, Yingying Zhang, Dechao Bu, Chao Wu, Shan Lu ,Zhihong Huang, Yurong Song, Yi Zhao, Fengying Guo, Peizhi Ye, Changgeng Fu, Liangliang Shen, Jingyuan Zhang, Haojia Wang, Xianchun Duan*, Jiarui Wu*. High Throughput Transcriptome Data Analysis and Computational Verification Reveal Immunotherapy Biomarkers of Compound Kushen Injection for Treating Triple-Negative Breast Cancer.Frontiers in Oncology. 2021. 11:p.747300.(通讯作者)
[7]Taohua Wei, Wenjie Hao, Lulu Tang, Huan Wu, Shi Huang, Yue Yang, Nannan Qian, Jie Liu, Wenming Yang* and Xianchun Duan*. Comprehensive RNA-Seq Analysis of Potential Therapeutic Targets of Gan-Dou-Fu-Mu Decoction for Treatment of Wilson Disease Using a Toxic Milk Mouse Model. Frontiers in Pharmacology. 2021. 12: p. 622268(通讯作者)
[8]Xianchun Duan, Lingyu Pan, Qiuyu Bao, Daiyin Peng*. UPLC-Q-TOF-MS Study of the Mechanism of THSWD for Breast Cancer Treatment. Frontiers in Pharmacology. 2019. 10: p. 1625.(第一作者)
[9]Xianchun Duan, Lingyu Pan, Daiyin Peng, Qiuyu Bao, Ling Xiao, An Zhou, Huan Wu, Can Peng, Weidong Chen. Analysis of the active components and metabolites of Taohong Siwu decoction by using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry. Journal of separation science.2020. 43(22): p. 4131-4147.(第一作者)
[10]Xianchun Duan, Lan Han, Daiyin Peng, Can Peng, Ling Xiao, Qiuyu Bao, Huasheng Peng. Bioinformatics analysis of a long non-coding RNA and mRNA regulation network in rats with middle cerebral artery occlusion based on RNA sequencing. Molecular medicine reports. 2019. 20(1): p. 417-432.(第一作者)
[11]Xianchun Duan, Lili Li, Jianghua Gan, Can Peng, Xiaoli Wang, Weidong Chen, Daiyin Peng*. Identification and functional analysis of circular RNAs induced in rats by middle cerebral artery occlusion. Gene. 2019. 701: p. 139-145.(第一作者)
[12]Xianchun Duan, Jianghua Gan, Daiyin Peng*, Qiuyu Bao, Ling Xiao, Liangbing Wei, Jian Wu. Identification and functional analysis of microRNAs in rats following focal cerebral ischemia injury. Molecular Medicine Reports. 2019. 19(5): p. 4175-4184.(第一作者)
[13]Xianchun Duan, Jianghua Gan, Fan Xu, Lili Li, Lan Han, Can Peng, Qiuyu Bao, Ling Xiao, Daiyin Peng*. RNA Sequencing for Gene Expression Profiles in a Rat Model of Middle Cerebral Artery Occlusion. Biomed Research International, 2018. 2018: p. 2465481.(第一作者)
[14] Xianchun Duan, Lan Han, Daiyin Peng*, Weidong Chen, Can Peng, Ling Xiao, Qiuyu Bao. High Throughput mRNA Sequencing Reveals Potential Therapeutic Targets of Tao-Hong-Si-Wu Decoction in Experimental Middle Cerebral Artery Occlusion. Frontiers in Pharmacology. 2018. 9: p. 1570.(第一作者)
[15]Xianchun Duan, Jianpeng Hu, Yongzhong Wang, Jiarong Gao, Daiyin Peng*, Lunzhu Xia*. MicroRNA-145: a promising biomarker for hepatocellular carcinoma (HCC). Gene. 2014. 541(1): p. 67-8.(第一作者)
[16]段贤春,黄石,彭代银,韩岚,汪小莉,汪永忠,潘凌宇.网络药理学在中药复方研究中的应用[J].中国药理学通报,2020,36(03):303-308.
[17]段贤春,周安,彭代银,鲍金云,夏伦祝.三七超临界CO2萃取物对谷氨酸损伤PC12细胞的保护作用[J].中国药理学通报,2017,33(12):1685-1690.
4、指导研究生情况
已毕业获学位硕士生6人,目前在读7人。
5、联系方式
Email: duanxc@ahtcm.edu.cn
地址:合肥市蜀山区梅山路117号安徽中医药大学第一附属医院