导师简介——段贤春
发布人:  发布时间:2026-03-02   浏览次数:

段贤春,男,1981年7月生,博士,教授,主任药师,硕士生导师,安徽省学术和技术带头人后备人选,安徽省首届卫生健康杰出人才,主要从事中药药理学研究。主持国家自然科学基金面上项目、安徽省自然科学基金青年项目等各类科研课题20余项,以第一作者或通讯作者发表论文50余篇(SCI收录25篇);获安徽省自然科学二等奖、中华中医药学会科技进步三等奖2项,国家发明专利2项(第一专利权人);参编高等中医药院校规划教材3部、学术著作5部(其中1部为副主编)、网络药理学研究方法标准1部,取得省级科研成果7项。多年来主要围绕中药复方物质基础及作用机制开展相关探索,聚焦以下研究方向:(1)中药复方网络药理学与系统生物学研究;(2)中医药防治缺血性中风作用机制研究;(3)医院药学研究。

1、主要社会兼职情况

现任世界中医药学会联合会网络药理学专业委员会常务理事、副秘书长,中华中医药学会青年委员、中药实验药理分会青年委员,安徽省药理学会理事。同时担任《江苏大学学报》(医学版)、《中国药房》编委,Phytomedicine、Journal of Ethnopharmacology等学术期刊审稿人,国家自然科学基金项目函审专家。

2、近年来主持科研项目情况

(1)国家自然科学基金面上项目/基于circDnajc1/miR-27a-5p/C1qc信号轴探讨小胶质细胞活化在缺血性中风神经元凋亡中的作用及桃红四物汤调控机制/2021年1月-2024年12月/55万/主持;

(2)安徽高校省级自然科学研究重点项目/基于网络药理学研究桃红四物汤防治缺血性中风主要物质基础及作用机制/2019年7月-2021年6月/6万/主持;

(3)安徽省教育厅/高校优秀拔尖人才培育项目/2019年7月-2021年6月/3万/主持;

(4)安徽省卫生健康委员会重点项目/基于脑肠轴探讨桃红四物汤对缺血性中风炎症损伤小鼠的保护作用及其机制/2022年9月-2024年8月/20万/主持;

(5)安徽省教育厅重点项目/桃红四物汤调控NCOA4介导铁自噬改善缺血性中风后铁死亡作用研究/2023年8月-2025年7月/10万/主持;

(6)安徽中医药大学“基础-临床融合” 专项(面上)项目/桃红四物汤通过 PANoptosis 信号通路调控缺血性中风时神经元损伤的作用及机制研究/ 2026年1月-2028年12月/40万/主持;

(7)安徽省中医药管理局重点项目/三叶鬼针草水提物对血压双向调节作用及对主动脉损伤保护机制研究/2025年11月-2027年10月/10万/主持。

3、近年来发表有代表性学术论文

[1] Shuangping Li, Jingjing Li, Yumeng Li, Qingping Ye , Ruru Wang, Xinyao Liu, Huining Li, Daiyin Peng, Xianchun Duan*. Regulation of NR4A1 by Taohong Siwu decoction inhibits endothelial cell apoptosis in cerebral Ischemia-Reperfusion injury. Journal of Ethnopharmacology.2025;353(Pt A):120285.(通讯作者)

[2] Shuangping Li, Qingping Ye, Yumeng Li, Jingjing Li, Chao Yu, Sujun Xue, Lijuan Zhang, Daiyin Peng, Shizhong Hong, Xianchun Duan*. Exploring the Role of Microglia Activation in Ischemia Stroke Based on the circDnajc1/miR-27a-5p/C1qc Signaling Axis. Molecular neurobiology. 2025;62(10):13073-13088.(通讯作者)

[3] Xinyao Liu, Ruru Wang, Yumeng Li, Jing Zhang, Jingjing Li, Shuangping Li, Qingping Ye, Renting Cao, Wen Wang, Wenhui Luo, Shujuan Beng, Xianchun Duan*, Can Peng. Development and preliminary mechanistic analysis of compound effervescent hepatoprotective granules. Frontiers in nutrition, 12, 1639561.(通讯作者)

[4] Yumeng Li, Qingping Ye, Jingjing Li, Lijuan Zhang, Chao Yu, Sujun Xue,Shuangping Li, Xianchun Duan*, Daiyin Peng. Exploring the mechanism of Taohong Siwu Decoction in treating ischemic stroke injury via the circDnajc1/miR-27a-5p/C1qc signaling axis. Phytomedicine. 2024, 136: 156305.(通讯作者)

[5] Yumeng Li, Chao Yu, Sujun Xue, Lijuan Zhang, Jingjing Li, Shuangping Li, Qingping Ye, Xianchun Duan*, Daiyin Peng, Taohong Siwu Decoction improves cerebral ischemia–reperfusion injury through SIRT1/FOXO1 signaling pathway, Journal of Functional Foods. 2024, 123: 106574.(通讯作者)

[6] Jingjing Li, Lijuan Zhang, Sujun Xue, Chao Yu, Yumeng Li, Shuangping Li, Qingping Ye , Xianchun Duan*, Daiyin Peng. Exploration of the mechanism of Taohong Siwu Decoction for the treatment of ischemic stroke based on CCL2/CCR2 axis. Frontiers in Pharmacology. 2024, 15: 1428572.(通讯作者)

[7] Shi Huang, Dan Yao, Chun Shan, Xiuli Du, Linyu Pan, Ni Wang, Yongzhong Wang, Xianchun Duan*, Daiyin Peng. The protective mechanism of Tao Hong Si Wu decoction against breast cancer through regulation of EGFR/ERK1/2 signaling. Journal of Ethnopharmacology. 2024, 332: 118339.(通讯作者)

[8] Lijuan Zhang, Sujun Xue , Changyi Fei , Chao Yu , Jingjing Li , Yumeng Li , Ni Wang , Ni Wang, Furui Chu, Lingyu Pan, Xianchun Duan* , Daiyin Peng. Protective effect of Tao Hong Si Wu Decoction against inflammatory injury caused by intestinal flora disorders in an ischemic stroke mouse model. BMC complementary medicine and therapies. 2024, 24(1): 124.(通讯作者)

[9] Ni Wang, Furui Chu, Lijuan Zhang, Changyi Fei, Chao Yu, Sujun Xue, Yongzhong Wang, Ling Fang, Daiyin Peng, Xianchun Duan*, Weidong Chen. Taohong siwu decoction attenuates AIM2 and NLRC4 inflammasomes by ameliorates deoxyribonucleic acid damage after ischemic stroke. Frontiers in Pharmacology. 2022, 13: 954867.(通讯作者)

[10] Lingyu Pan, Can Peng, Lei Wang, Lili Li, Shi Huang, Changyi Fei, Ni Wang, Furui Chu, Daiyin Peng, Xianchun Duan*. Network pharmacology and experimental validation-based approach to understand the effect and mechanismof Taohong Siwu Decoction against ischemic stroke. Journal of Ethnopharmacology. 2022, 294: 115339.(通讯作者)

[11] Ni Wang, Furui Chu, Changyi Fei, Lingyu Pan, Yongzhong Wang, Weidong Chen, Daiyin Peng, Xianchun Duan*, Ling He. Naoluo Xintong decoctionin the treatment of ischemic stroke: A network analysis of the mechanism of action. Frontiers in Pharmacology. 2022, 13: 809505.(通讯作者)

[12] Shi Huang, Yan Chen, Lingyu Pan, Changyi Fei, Ni Wang, Furui Chu, Daiyin Peng, Xianchun Duan*, Yongzhong Wang*. Exploration of the PotentialMechanism of Tao Hong Si Wu Decoction for the Treatment of Breast CancerBased on Network Pharmacology and In Vitro Experimental Verification. Frontiers in Oncology. 2021, 12: 732358.(通讯作者)

[13] Ni Wang, Changyi Fei, Furui Chu, Shi Huang, Lingyu Pan, Daiyin Peng, Xianchun Duan*. Taohong Siwu Decoction Regulates Cell Necrosis and Neuroinflammation in the Rat Middle Cerebral Artery Occlusion Model. Frontiers in Pharmacology. 2021, 12: 732358.(通讯作者)

[14] Xinkui Liu, Yang Wu, Yingying Zhang, Dechao Bu, Chao Wu, Shan Lu ,Zhihong Huang, Yurong Song, Yi Zhao, Fengying Guo, Peizhi Ye, ChanggengFu, Liangliang Shen, Jingyuan Zhang, Haojia Wang, Xianchun Duan*, Jiarui Wu. High Throughput Transcriptome Data Analysis and Computational Verification Reveal Immunotherapy Biomarkers of Compound Kushen Injection for Treating Triple-Negative Breast Cancer. Frontiers in Oncology. 2021, 11: 747300.(通讯作者)

[15] Taohua Wei, Wenjie Hao, Lulu Tang, Huan Wu, Shi Huang, Yue Yang, Nannan Qian, Jie Liu, Wenming Yang, Xianchun Duan*. Comprehensive RNA-Seq Analysis of Potential Therapeutic Targets of Gan-Dou-Fu-Mu Decoction for Treatment of Wilson Disease Using a Toxic Milk Mouse Model. Frontiers in Pharmacology. 2021, 12: 622268. (通讯作者)

4、指导研究生情况

已毕业获学位硕士生12人,目前在读7人。

5联系方式

Email: duanxc@ahtcm.edu.cn

地址:合肥市蜀山区梅山路117号安徽中医药大学第一附属医院