导师简介——李海波
发布人:  发布时间:2024-01-15   浏览次数:

李海波,女,博士,暨南大学博士后,高级工程师,江苏省产业教授(研究生导师类)。主要从事中药及中药复方药效物质基础及作用机制研究、质量控制研究工作。近五年,发表论文49篇(其中以第一或通讯作者发表SCI 论文24篇,中文核心期刊8篇),参与编写专著《解码中成药》1本(编委),申请发明专利16项,授权11项,获广东省科技进步一等奖1项,入选江苏省第六期“333高层次人才培养工程”中青年学术技术带头人。作为项目负责人和技术骨干,承担多项省部级以上重大科技项目,为大品种上市后再评价研究、新技术应用做出了重要贡献。

一、近5年代表性论文:

[1] Ling-xian Liu1, Hai-bo Li 1, Jia-ying Zhang, Dan-feng Shi, Zhen-zhong Wang, Xin-sheng Yao*, Wei Xiao*, Yang Yu*. Quality markers screening of traditional Chinese medicine prescriptions based on the multi-factor analysis strategy: Jin-Zhen oral liquid as a case. Arabian Journal of Chemistry, 2024, 17: 105433.

[2] Junran Shao, Ting Li, Siying Zeng, Jie Dong, Xinyi Chen, Caixia Zang , Xinsheng Yao, Haibo Li*, Yang Yu*. The structures of two acidic polysaccharides from Gardenia jasminoides and their potential immunomodulatory activities. International Journal of Biological Macromolecules, 2023, 248: 125895.

[3] Jie Dong, Mi Zhou, Da-bo Pan, Qian-yu Qin, Ting Li, Xin-sheng Yao*, Hai-bo Li * and Yang Yu *. Eremophilane and cadinane sesquiterpenoids from the fruits of Alpinia oxyphylla and their anti-inflammatory activities Food Funct., 2023, 14: 9755.

[4] Dong Jie, Geng Jianliang, Zhou Mi, Yao Xinsheng*, Li Haibo*, Yu Yang*. Four new diarylheptanoids and two new terpenoids from the fruits of Alpinia oxyphylla and their anti-inflammatory activities. Chin J Nat Med, 2023, DOI: https://doi.org/10.1016/S1875-5364(23)60519-9.

[5] Weirong Bai, Tuanjie Wang, Xiaoming Yang, Zhenzhong Wang, Haibo Li* and Jianliang Geng*.Two new sesquiterpenoids from the fruits of Alpinia oxyphylla. Natural Product Research, 2023, DOI: DOI: 10.1080/14786419.2023.2272282.

[6] Mi Zhou, Ting Li, Chen Zeng, Da-bo Pan, Hai-bo Li* and Yang Yu*. Two new diterpenoids from the rhizomes of Zingiber officinale. Natural Product Research, 2023, 37(13): 2255-2262.

[7] Xiao-qing He, Hai-bo Li*, Ting Li, Xin-yin Chen, Zhen-zhong Wang*, Xin-sheng Yao, Wei Xiao and Yang Yu. One undescribed glycoside benzofuran derivative and a new p-hydroxybenzoate glycoside from the leaves of Illicium dunnianum Tutcher. Natural Product Research, 2023, DOI: 10.1080/14786419.2023.2216348.

[8] Jun-Ran Shao, Sen-Ju Ma, Ting Li, Xiao-Qing He, Zhen-Zhong Wang, Wei Xiao,

Xin-Sheng Yao, Hai-Bo Li*, Yang Yu*.Two new chemical constituents from the leaves of Illicium dunnianum. Natural Product Research, 2023, 37(8): 1233-1240.

[9] Hai-Bo Li, Jin-Feng Ma, Yu-Dan Mei, Ling-Xian Liu, Ze-yu Cao, Dan-Feng Shi, Xin-Sheng Yao* and Yang Yu*. Two new iridoid glycosides from the fruit of Gardenia jasminoides. Natural Product Research, 2022, 36(1): 186-192.

[10] Sen-Ju Ma1, Hai-Bo Li 1, Jun-Ran Shao, Qian-Qian Pang, Ting Li, Xin-Sheng Yao and Yang Yu. Two new chemical constituents from the rhizomes of Actaea dahurica. Natural Product Research, 2022, 36(7): 1789-1796.

[11] Hai-bo Li, Sen-ju Ma, Ying-xin Shan, Ting Li, Zhen-zhong Wang*, Wei Xiao, Zuo-cheng Qiu* and Yang Yu*. Eight new phenolic acids from the leaves of Illicium dunnianum and their osteoprotective activities. RSC Advances, 2022, 12: 21655.

[12] Jian-liang Geng#, Hai-bo Li# (co-first), Wen-jun Liu, Zhen-zhong Wang, Wen Ge, Wei Xiao.  Two new chemical constituents from Lonicera japonica, Natural Product Research, 2022, 36(20): 5174-5180.

[13] Ling-Xian Liu, Liang Cao, Dan-Feng Shi, Zhen-Zhong Wang, Wei Xiao, Xin-Sheng Yao, Hai-Bo Li*, Yang Yu*. Metabolic profiles of Jin-hong tablets in rats by ultraperformance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry, Biomedical Chromatogaphy, 2021, 35(6): e5072.

[14] Da-peng Qin, Ting Li, Jun-ran Shao, Xiao-qing He, Dan-feng Shi, Zhen-zhong Wang, Wei Xiao, Xin-sheng Yao, Hai-bo Li*, Yang Yu*.  Arteannoides U–Z: Six undescribed sesquiterpenoids with anti-inflammatory activities from the aerial parts of Artemisia annua (Qinghao), Fitoterapia, 154 (2021) 105002.

[15] Pang Qian-qian, Li Ting, Liu Ling-xian, Shi Dan-feng, Yao Xin-sheng, Li Hai-bo*, Yu Yang*. Systematically identifying the anti-inflammatory constituents of Cimicifuga dahurica by UPLC Q/TOF–MS combined with network pharmacology analysis, Biomedical Chromatogaphy, 2021,35(12): e5177.

[16] Sen-Ju Ma#, Hai-Bo Li# (co-first), Ting Li, Zhen-Zhen Su, Zhen-Zhong Wang, Xin-Sheng Yao, Wei Xiao, Yang Yu. Illiciumlignans G–O from the leaves of Illicium dunnianum and their anti-inflammatory activities, RSC advances, 2021, 11: 30725.

[17] Ting Li, Da-bo Pan, Qian-qian Pang, Mi Zhou, Xiao-jun Yao, Xin-sheng Yao, Hai-bo Li*, Yang Yu*. Diarylheptanoid analogues from the rhizomes of Zingiber officinale and their anti-tumour activity, RSC advances, 2021, 11: 29376.

[18] Yu-Dan Mei#, Hai-Bo Li#(co-first), Ling-Xian Liu, Dan-feng Shi, Da-bo Pan, Xin-Sheng Yao, Yang Yu.  A new nitrogen-containing iridoid glycoside from lonicera macranthoides [J], Nature product research, 2021, 35(20): 3422-3438.

[19] Qian-Qian Pang, Yu-Dan Mei, Yuan-Chu Zhang, Ling-Xian Liu, Dan-Feng Shi, Da-Bo Pan, Xin-Sheng Yao, Hai-Bo Li*, Yang Yu*. Three new cycloart-7-ene triterpenoid glycosides from Cimicifuga dahurica and their anti-inflammatory effects[J], Nature product research, 2021, 35(21): 3634-3643.

[20] 李海波,黄玉欣,秦大鹏,曹亮,王振中,姚新生,于洋.青蒿中 1 个新的生物碱类化合物, 中草药, 2021, 52(2): 327-330

[21] 葛雯,杨彪,于洋,康经武,李海波*,王振中*. 高效毛细管电泳法测定热毒宁注射液中阴阳离子和小分子有机酸成分的含量,世界科学技术-中医药现代化, 2021, 22(11): 3913-3918.

[22] Hai-bo Li, Biao Yang, Wen Ge, Ze-yu Cao, Liang Cao, Yang Yu, Zhen-zhong Wang, Xin-sheng Yao, Wei Xiao. Two new terpenoids from Reduning injection [J]. Chinese Herbal Medicines, 2020, 12: 183-187.

[23] Da-Peng Qin*, Hai-Bo Li* (co-first), Qian-Qian Pang, Yu-Xin Huang, Da-Bo Pan, Zhen-Zhen Su, Xiao-Jun Yao, Xin-Sheng Yao, Wei Xiao,Yang Yu. Structurally diverse sesquiterpenoids from the aerial parts of Artemisia annua (Qinghao) and their striking systemically anti-inflammatory activities. Bioorganic Chemistry, 2020, 103: 104221.

[24] 李海波, 马森菊, 石丹枫, 王振中, 姚新生, 于 洋, 肖 伟.川楝子的化学成分、药理作用及其毒性研究进展, 中草药, 2020, 51(15): 4059-4074.

[25] 李海波,王团结,杨 群,刘苓娴,马森菊,曹 亮,王振中,姚新生,于 洋,肖伟.金振口服液HPLC-UVD-ELSD特征指纹图谱及13个成分同时定量的整体质量控制研究,中草药,2020, 51(22): 5737-5747.

[26] 李海波,杨群,区伟珍,王团结,曹亮,王振中,姚新生,于洋,肖伟. 金振口服液氨基酸特征指纹图谱及29种氨基酸同时定量的质量控制方法, 2020, 51(23): 5972-5979.

[27] 李海波,马金凤,庞倩倩,梅玉丹,王振中,姚新生,于 洋. 栀子的化学成分研究, 中草药,2020, 51(22): 5687-5697.

[28] Wen Ge#, Hai-Bo Li#(co-first), Hui Fang, Biao Yang, Wen-Zhe Huang, Wei Xiao & Zhen-Zhong Wang. A new dimeric secoiridoids derivative, japonicaside E, from the flower buds of Lonicera japonica [J]. Nature product research, 2019, 33 (1): 53-58.

[29] Yu-Dan Mei#, Hai-Bo Li#(co-first), Qian-Qian Pang, Ting Li, Da-Bo Pan, Yi Dai, Da-Peng Qin, He Meng, Xin-Sheng Yao, Yang Yu. Lonimacranaldes A~C, three iridoids with novel skeletons from Lonicera macranthoides [J], RSC advances, 2019, 9: 22011-22016.

[30] Lu Qing#, Li Hai-bo#(co-first), Pang Qian-qian, Zhang Wei-yang, Su Zhen-zhen, Pan Da-bo, Yao Xin-Sheng, Yu Yang. New phenylpropanoid allopyranosides from the rhizomes of Cimicifuga dahurica [J], Bioorganic & Medicinal Chemistry Letters, 2019, 29 (14): 1774-1778.

[31] 李海波,秦大鹏,葛 雯,王振中,曹 亮,肖 伟,于 洋,姚新生. 青蒿化学成分及药理作用研究进展 [J]. 中草药, 2019,50 (17): 4189-4199.

[32] Hai-bo Li, Ying Shi, Qianqian Pang, Yudan Mei, Zhenzhen Su, Xin-Sheng Yao, Yang Yu. Monoterpene glycosides with anti-inflammatory activity from Paeoniae Radix [J], Fitoterapia, 2019, 138: 1042901.