周安,男,博士,教授,硕士生导师。现任科研实验中心分析检测室主任,安徽省色谱分析学会医药色谱专业委员会委员。主要承担本科生《药物分析》、《仪器分析》和研究生《现代仪器分析》等课程的教学工作。参编全国普通高等教育“十二五”规划教材《分析化学》教材1部与《新药发现与开发》专著1部。作为项目主持人完成国家级、省部级课题6项。发表论文50余篇,其中SCI收录20余篇。获得安徽省药学会优秀学术论文一等奖2项,安徽省中医药学会科学技术二等奖1项,安徽省药学会第三届“曼迪新”药学优秀学术论文二等奖1项,申请国家发明专利3项,已授权1项。
(1)近年主持主要课题
1.国家自然科学基金面上项目:基于中药配位化学理论探究复方肝豆汤通过驱铜途径治疗肝豆状核变性的药效物质基础(81872976)2019-2022 ,57万元,主持人
2. 国家自然科学基金青年基金项目:基于脑靶向特性研究定志小丸中石菖蒲引药上行作用机理(81303245),2014-2016, 23万元,主持人
3. 国家中医药管理局委托专项:“疏风解毒胶囊标准化建设项目”连翘品种研究(ZYBZH-C-AH-02),2017-2019,30万元,主持人
4.安徽高校省级自然科学研究重点项目:基于体内吸收环节研究定志小丸中石菖蒲引药上行作用机理(KJ2013A171),2013-2015, 7.5万元,主持人
5.安徽道地中药材品质提升协同创新中心2011创新项目:霍山石斛鲜药超高压加工工艺研究(2011xtcx007),2015-2018,10万元,主持人
(2)近年发表的主要论文
1.Meimei Chenga, Huan Wua, Hongfei Wu, Xiaochuang Liu, An Zhou(通讯作者),∗Metabolic profiling of copper-laden hepatolenticular degeneration model rats and the interventional effects of Gandou decoction using UPLC-Q-TOF/MS,Journal of Pharmaceutical and Biomedical Analysis, 2019,164(5) 187-195.
2.Juan Liang,Sai Guo,An Zhou(通讯作者), Ai Ling Hui, Kai Zong,Nian Jun Yu,Dai Yin Peng.Effect of high‐pressure processing on the polysaccharides content and antioxidant activity of fresh Dendrobiumofficinale juice,Journal of food biochemistry,2018,DOI: 10.1111/jfbc.12609.
3.刘玉梅,周安(通讯作者), 俞年军, 韩荣春, 张威, 朱月健, 曹勇, 李翔宇, 彭代银. HPLC-DAD双波长法同时测定柴胡中5种皂苷的含量[J]. 中国中药杂志, 2018(2):363-368.
4.刘艺,程梅梅,董健健,周安. 外翻肠囊法研究肝豆汤醇提物主要成分的肠吸收特征[J]. 中国中药杂志,2017,42(13):2571-2576.
5.Hui, Ailing,Zhu, Shijing,Yin, Huayang,Yang, Li,Zhang, Zheng,Zhou An(通讯作者),Pan, Jian,Zhang, Wencheng,Novel ginkgolide B derivative attenuated the function and expression of P-glycoprotein at the blood-brain barrier, presenting brain-targeting ability,Rsc Advances,2016.06.09,6(37):31101~31106.
6. Zhou An ,Wang B, Duan X, Wang H. 3D-QSAR and Molecular Docking Studies of Flavonoid Derivatives as Potent Acetylcholinesterase Inhibitors [J]. Letters in Drug Design & Discovery, 2015,12(10):837-843.
7. Zhou An, Hongfei W, Jian P, Xuncui W, Jiaming L, Zeyu W. Synthesis and evaluation of paeonol derivatives as potential multifunctional agents for the treatment of Alzheimer’s Disease [J]. Molecules, 2015, 20(1): 1304-1318.
8. Zhou A, Hu J, Wang L, Zhong G, Pan J. Combined 3D-QSAR, molecular docking and molecular dynamics study on tacrine derivatives as potential acetylcholinesterase (AChE) inhibitors against Alzheimer's disease [J]. Journal of Molecular Modeling, 2015, 21(10): 1-12.
9.An Zhou, Tao Lu, Lei Wang, Chuanhua Lu, Lina Wang, Maolin Wan, and Hongfei Wu. Lymphatic transport of puerarin occurs after oral administration of different lipid-based formulations to unconscious lymph duct cannulated rats. Pharmaceutical Development and Technology. 2013, 19(6):743-747.
10.An ZHOU, Hongfei WU*, Daiyin PENG, Qinglin LI,Xiaojuan SUN.Qualitative and quantitative analyses of three bioactive compounds in traditional Chinese medicine gamboge by HPLC–PDA–ESI/MSn.Latin American Journal of Pharmacy. 2011, 30(8):1267-1272.
11. Hongfei Wu, An Zhou (Co-author), Chuanhua Lu*,Lei Wang .Examination of lymphatic transport of puerarin in unconscious lymph duct-cannulated rats after administration in microemulsion drug delivery systems . European Journal of Pharmaceutical Sciences.2011,42(4): 348-353.
12.Hui Ailing,Chen Yan,Zhu Shijing,Gan Changsheng,Pan Jian,Zhou An,Design and synthesis of tacrine-phenothiazine hybrids as multitarget drugs for Alzheimer's disease,Medicinal Chemistry Research,2014.7.01,23(7):3546~3557.
13.周安,纪娟,陈苏菲,吴雷,吴虹,王斌,刘晓闯,吴鸿飞. 复方定志小丸正丁醇提部位的HPLC-ELSD指纹图谱研究[J]. 药物分析杂志,2014,34(05):907-911.
14.周安,孙晓娟,吴虹,李庆林,吴鸿飞. 高效液相色谱电喷雾质谱快速鉴定粉葛中C-苷及O-苷同分异构体[J]. 分析化学,2012,40(04):612-616.
15.周安,李庆林,彭代银,吴鸿飞,王效山. 高效液相色谱-质谱联用法鉴定中药藤黄中桥环类化合物[J]. 药学学报,2008(08):838-842.
(3)主要研究方向
1.药物分析新技术和方法研究;
2.药物作用有效性与活性成分相关性研究;
3.中药质量控制与评价。
(4)指导硕士研究生情况
2012年开始指导硕士研究生,现指导硕士研究生12名,已毕业获硕士学位7人,两人获得研究生国家奖学金。
联系方式
办公电话:0551-65169752
邮箱:anzhou@ahtcm.edu.cn;anzhou0901@163.com.